Oh my gosh yes - I was the executive assistant to a female president of a credit union.  She was in her mid 50's and Hormonal (please note the capital).  We had a turn over rate of over 40% for approximately 25 employees.  She could cry and scream in the same five minute period, demanding, and make requests that were not professional. I've blocked out the worst of it.  I lasted 18 months and the Board of Directors came in and asked her to resign.  I had to go to the basement to do the Snoopy Happy Dance to get the big grin off my face to be able to face the rest of the employees and board members.  That didn't really help me though - it took the board nine months to find a replacement, the interium candidate who looked most promising demanded his management team all have bachelors.  (Guess who doesn't have a degree?  I thought this unfair since I have been performing "satisfactorily" for the last year and half.)  So I left, and the same week the interium candidate took a job at a Miami credit union.
Circle of Life - I LOVE my current job, have great bosses, benefits and enjoy the work.  It's not work if you like the job.  I think we all have to pay our dues to appreciate when we do find the perfect fit job.  I also think we have to be able to accept that change is going to happen and prepare for it.